| The Effect of Combination of Radiation with 5-luorouracil on Mouse Jejunal Crypt Cells |
| Seung Jae Huh, Charn Il Park |
1Department of Radiology, College of Medicine, Soonchunhyang University, Korea.
2Department of Therapeutic Radiology, College of Medicine, Seoul National University, Korea. |
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| ABSTRACT |
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The interaction of radiation and 5-luorouracil (5-U) on mouse jejunal crypt cells was studied using the microcolony survival assay. 150mg/kg of 5-U was injected intraperitoneally 15 minutes before irradiation and 6 hours after irradiation. Jejunal crypt cells of mouse survived more when 5-U was given 15 minutes before irradiation than giving it 6 hours after irradiation. The mean lethal doses (Do) of each of irradiation alone group, 5-U injection group of 15 minutes preceding irradiation, and 5-U injection group of 6 hours post irradiation were. 135, 135, and 114 rad respectively. The dose effect factor (DEF) of each of 5-U injection groups of 15 minutes preceding irradiation and of 6 hours post irradiation were 1.13 and 1.27. |
| Key Words:
Radiation, 5-U, Mouse jejunal crypt, Interaction |
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