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J Korean Soc Ther Radiol > Volume 3(2); 1985 > Article
Journal of the Korean Society for Therapeutic Radiology 1985;3(2): 87-94.
The Effect of Combination of Radiation with 5-luorouracil on Mouse Jejunal Crypt Cells
Seung Jae Huh, Charn Il Park
1Department of Radiology, College of Medicine, Soonchunhyang University, Korea.
2Department of Therapeutic Radiology, College of Medicine, Seoul National University, Korea.
The interaction of radiation and 5-luorouracil (5-U) on mouse jejunal crypt cells was studied using the microcolony survival assay. 150mg/kg of 5-U was injected intraperitoneally 15 minutes before irradiation and 6 hours after irradiation. Jejunal crypt cells of mouse survived more when 5-U was given 15 minutes before irradiation than giving it 6 hours after irradiation. The mean lethal doses (Do) of each of irradiation alone group, 5-U injection group of 15 minutes preceding irradiation, and 5-U injection group of 6 hours post irradiation were. 135, 135, and 114 rad respectively. The dose effect factor (DEF) of each of 5-U injection groups of 15 minutes preceding irradiation and of 6 hours post irradiation were 1.13 and 1.27.
Key Words: Radiation, 5-U, Mouse jejunal crypt, Interaction
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