Changes in Plasma Prolaction and Growth Hormone Level and Visual Problem after radiation Therapy(RT) of Pituitary Adenoma

Yoon,  Sei Chul; Kwon,  Hyung Chul; Oh,  Yoon Kyeong; Bahk,  Yong Whee; Son,  Ho Yong; Kang,  Joon Ki; Song,  Jin Un

J Korean Soc Ther Radiol > Volume 3(1); 1985 > Article

Original Article

Journal of the Korean Society for Therapeutic Radiology 1985;3(1): 19-28.

Changes in Plasma Prolaction and Growth Hormone Level and Visual Problem after radiation Therapy(RT) of Pituitary Adenoma

Sei Chul Yoon, Hyung Chul Kwon, Yoon Kyeong Oh, Yong Whee Bahk, Ho Yong Son, Joon Ki Kang, Jin Un Song

¹Division of Radiation Therapy Kang-am St. Mary's Hospital, Catholic Medical College, Seoul, Korea.
²Department of Internal Medicine & Neourosurgery Kang-am St. Mary's Hospital, Catholic Medical College, Seoul, Korea.

ABSTRACT

Twenty-our cases of pituitary adenoma, 13 males and 11 females with the age ranging from 11 to 65 years, received radiation therapy(RT) on the pituitary area with 6MV linear accelerator during past 25 months at the Division of Radiation Therapy, Kangnam St. Mary's Hospital, Catholic Medical College. Of 24 case of RT, 20 were postoperative and 4 primary. To evaluate the effect of RT, we analyzed the alteration of the endocrinologic tests, neurologic abnormalities, major clinical symptoms, endocrinologic changes and improvement in visual problems after RT. The results were as follows ; 1. Major clinical symptoms were headache, visual defects, diabetes insipidus, hypogonadisms and general weakness in decreasing order of frequency. 2. All but the one with Nelson's syndrome showed abnormal neuroradiologic changes in the sella turcica with an invasive tumor mass around supra and para-ellar area. 3. Endocrinological classifications of the patient were 11 prolactinoma, 4 growth hormonesecreting tumors, 3 ACTH-ecreting tumors consisting of one Cushing's disease and two Nelson's syndrome, and 6 nonfunctioning tumors. 4. Eleven of 14 patients, visual problems were improved after treatment but remaining 3 were unchanged. 5. Seven of 11 prolactinomas returned to normal hormonal level after postoperative and primary RT and 3 patients are being treated with bromocriptine (BMCP) but on lost case. 6. Two of 4 growth hormone-ecreting tumor returned to normal level after RT but the remaining 2 are being treated with BMCP, as well.