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Table of Contents | , 2000  Vol. 18  No.4 Previous Issue | Next Issue | Archive
In this issue:

Original Articles
Comparison of New AJCC Staging System with Old AJCC Staging System in Nasopharyngeal Carcinoma
Semie Hong, Hong Gyun Wu, Charn Il Park
Radiat Oncol J. 2000;18(4):221-225.
PURPOSE: This study was designed to examine the reliability of the new version of the AJCC staging system (1997) of nasopharyngeal carcinoma in comparison with the AJCC staging system of 1992. MATERIALS AND METHODS: Between 1983 and 1996, 185 patients with histologically proven nasopharyngeal carcinoma were treated with radiation therapy at the Department of Therapeutic Radiology Seoul National University Hospital. For these...
Prognostic Factors for Local Control in Early Glottic Cancer Treated with Radiation Therapy
Woong Ki Chung, Sung Ja Ahn, Taek Keun Nam, Byung Sik Nah, Jae Shik Cho, Sang Chull Lim
Radiat Oncol J. 2000;18(4):226-232.
PURPOSE: This study was performed to find out the prognostic factors affecting local control in early glottic cancer treated with radiation therapy alone. MATERIALS AND METHODS: We analysed 37 patients of histologically confirmed early glottic cancer treated at Chonnam National University Hospital between July 1986 and December 1995, retrospectively. Age of patients ranged from 30 to 73 years (median; 59 years)....
The Role of Primary Radiotherapy for Squamous Cell Carcinoma of the Supraglottic Larynx
Won Taek Kim, Dong Won Kim, Byung Hyun Kwon, Ji Ho Nam, Won Joo Hur
Radiat Oncol J. 2000;18(4):233-243.
BACKGROUND: First of all, this study was performed to assess the result of curative radiotherapy and to evaluate different possible prognostic factors for squamous cell carcinoma of the supraglottic larynx treated at the Pusan National University Hospital. The second goal of this study was by comparing our data with those of other study groups, to determine the better treatment policy...
Neoadjuvant Chemotherapy and Radiotherapy in Locally Advanced Hypopharyngeal Cancer
Suzy Kim, Hong Gyun Wu, Dae Seog Heo, Charn Il Park
Radiat Oncol J. 2000;18(4):244-250.
PURPOSE: To see the relationship between the response to chemotherapy and the final outcome of neoadjuvant chemotherapy and radiotherapy in patients with locally advanced hypopharyngeal cancer. METHODS AND MATERIALS: A retrospective analysis was done for thirty-two patients with locally advanced hypopharyngeal cancer treated in the Seoul National University Hospital with neoadjuvant chemotherapy and radiotherapy from August 1979 to July 1997. The...
Preliminary Results of Stereotactic Radiosurgery Using Stereotactic Body Frame
Seung Do Ahn, Byong Yong Yi, Eun Kyung Choi, Jong Hoo Kim, Young Ju Nho, Kyung Hwan Shin, Kyoung Ju Kim, Won Kyun Chung, Hyesook Chang
Radiat Oncol J. 2000;18(4):251-256.
PURPOSE: To evaluate efficacy and complication of stereotactic radiosurgery using stereotactic body frame. METHODS AND MATERIALS: From December 1997 to June 1999, 11 patients with primary and metastatic tumors were treated with stereotactic radiosurgery using stereotactic body frame(Precision Therapy(TM)). Three patients were treated with primary hepatoma and seven with metastatic tumor from liver, lung, breast, trachea and one with arteriovenous malformation...
Radiotherapy in Medically Inoperable Early Stage Non-small Cell Lung Cancer
Bo Kyoung Kim, Charn Il Park
Radiat Oncol J. 2000;18(4):257-264.
PURPOSE: For early stage non-small-cell lung cancer, surgical resection is the treatment of choice. But when the patients are not able to tolerate it because of medical problem and when refuse surgery, radiation therapy is considered an acceptable alternative. We report on the treatment results and the effect of achieving local control of primary tumors on survival end points, and...
The Use of Normal Tissue Complication Probability to Predict Radiation Hepatitis
Ki Chang Keum, Jinsil Seong, Chang Ok Suh, Sang wook Lee, Eun Ji Chung, Hyun Soo Shin, Gwi Eon Kim
Radiat Oncol J. 2000;18(4):277-282.
PURPOSE: Although It has been known that the tolerance of the liver to external beam irradiation depends on the irradiated volume and dose, few data exist which quantify this dependence. However, recently, with the development of three dimensional (3-D) treatment planning, have the tools to quantify the relationships between dose, volume, and normal tissue complications become available. The objective of...
Efficacy of a Preoperative Concurrent Chemoradiotherapy for the Locally Advanced Unresectable Rectal Cancer
Jae Ho Cho, Jinsil Seong, Ki Chang Keum, Gwi Eon Kim, Chang Ok Suh, Jae Kyung Roh, Hyun Cheol Chung, Jin Sik Min, Nam Kyu Kim
Radiat Oncol J. 2000;18(4):293-299.
PURPOSE: We conducted a prospective non-randomized clinical study to evaluate the efficacy and toxicity of the preoperative concurrent chemoradiotherapy for locally advanced unresectable rectal cancer. MATERIALS AND METHODS: Between January 1995 and June 1998, 37 consecutive patients with locally unresectable advanced rectal cancer were entered into the study. With 3- or 4- fields techniuqe, a total of 45 Gy radiation was...
An Analysis of Prognostic Factors in the Uterine Cervical Cancer Patients
Dae Sik Yang, Won Sub Yoon, Tae Hyun Kim, Chul Yong Kim, Myung Sun Choi
Radiat Oncol J. 2000;18(4):300-308.
PURPOSE: The aim of this study is to analysis of survival and recurrence rates of the uterine cervical carcinoma patients whom received the radiation therapy respectively. The prognostic factors, such as Papanicolaou (Pap) smear, carcinoembriogenic antigen (CEA) and squamous cell carcinoma (SCC) antigen has been studied. METHODS AND MATERIALS: From January 1981 to December 1998, eight-hundred twenty-seven uterine cervical cancer patients were...
Metastatic Cervical Lymphadenopathy from Uterine Leiomyosarcoma with Good Local Response to Radiotherapy and Chemotherapy
Yoon Kyeong Oh, Hee Chul Park, Keun Hong Kee, Ho Jong Jeon, You Hwan Park, Choon Hai Chung
Radiat Oncol J. 2000;18(4):309-313.
The metastasis of uterine leiomyosarcoma to the neck node has not been reported previously and the radiotherapy has been rarely used for the metastatic lesion of the other sites. We report a case of neck metastasis from a uterine leiomyosarcoma, which developed 10 months after surgery and postoperative pelvic radiotherapy. It also involved the parapharyngeal space, adjacent spine, and spinal...
The Measurements of Plasma Cytokines in Radiation-induced Pneumonitis in Lung Cancer Patients
Won Joo Hur, Seon Min Youn, Hyung Sik Lee, Kwang Mo Yang, Sin Geun Oh, Choon Hee Son, Jin Yeong Han, Ki Nam Lee, Min Ho Jeong
Radiat Oncol J. 2000;18(4):314-320.
PURPOSE: To investigate whether changes in plasma concentrations of transforming growth factor-beta1 (TGF-beta1), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) could be used to identify the development of radiation-induced pneumonitis in the lung cancer patients. METHODS AND MATERIALS: Seventeen patients with lung cancer (11 NSCLC, 6 SCLC) were enrolled in a prospective study designed to evaluate clinical and molecular biologic correlation...
Radiation Effect on NO, NOS and TGF-beta Expressions In Rat Lung
Young Taek Oh, Kwang Joo Park, Hoon Jong Kil, Mahn Joon Ha, Mison Chun, Seung Hee Kang, Seong Eun Park, Sei Kyung Chang
Radiat Oncol J. 2000;18(4):321-328.
PURPOSE: NOS2 induce NO production and NO activate TGF-beta. The TGF-beta is a inhibitor of NOS2. If this negative feedback mechanism operating in radiation pneumonitis model, NOS2 inhibitor may play a role in TGF-beta suppression. We planned this study to evaluate the expression patterns of NO, NOS2 and TGF-beta in vivo radiation pneumonitis model. MATERIALS AND METHODS: Sixty sprague-Dawley rat were irradiated...
A CT Simulator Phantom for Geometrical Test
Chul Kee Min, Byong Yong Yi, Seung Do Ahn, Eun Kyung Choi, Hyesook Chang
Radiat Oncol J. 2000;18(4):329-336.
PURPOSE: To design and test the CT simulator phantom for geometrical test. MATERIAL AND METHODS: The PMMA phantom was designed as a cylinder which is 20 cm in diameter and 24 cm in length, along with a 25x25x31 cm3 rectangular parallelepiped. Radio-opaque wires of which diameter is 0.8 mm are attached on the other surface of the phantom as a spiral. The...
Enhancement of Tumor Radioresponse by Combined Chemotherapy in Murine Hepatocarcinoma
Jinsil Seong, Sung Hee Kim, Chang Ok Suh
Radiat Oncol J. 2000;18(4):337-344.
BACKGROUNDS: The purpose of this study was to identify drugs that can enhance radioresponse of murine hepatocarcinoma. METHODS: C3H/HeJ mice bearing 8 mm tumors of murine hepatocarcinoma, HCa-I, were treated with 25 Gy radiation and one of the following drugs: 5-Fu, 150 mg/kg; adriamycin, 8 mg/kg; cisplatin, 6 mg/kg; paclitaxel, 40 mg/kg; and gemcitabine, 50 mg/kg. Tumor response to the treatment...
Enhancement of Image Contrast in Linacgram through Image Processing
Hyun Suk Suh, Hyun Kyo Shin, Rena Lee
Radiat Oncol J. 2000;18(4):345-354.
PURPOSE: Conventional radiation therapy portal images gives low contrast images. The purpose of this study was to enhance image contrast of a linacgram by developing a low-cost image processing method. MATERIALS AND METHODS: Chest linacgram was obtained by irradiating humanoid phantom and scanned using Diagnostic-Pro scanner for image processing. Several types of scan method were used in scanning. These include optical...
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