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Table of Contents | June, 2015  Vol. 33  No.2 Previous Issue | Next Issue | Archive
In this issue:



Review Articles
Stereotactic radiotherapy for early stage non-small cell lung cancer
Umberto Ricardi, Serena Badellino, Andrea Riccardo Filippi
Radiat Oncol J. 2015;33(2):57-65.   Published online June 30, 2015

Stereotactic body radiotherapy (SBRT) represents a consolidated treatment option for patients with medically inoperable early stage non-small cell lung cancer (NSCLC). The clinical evidence accumulated in the past decade supports its use as an alternative to surgery with comparable survival outcomes. Due to its limited toxicity, SBRT is also applicable to elderly patients with very poor baseline pulmonary function or...

The protective effects of trace elements against side effects induced by ionizing radiation
Seyed Jalal Hosseinimehr
Radiat Oncol J. 2015;33(2):66-74.   Published online June 30, 2015

Trace elements play crucial role in the maintenance of genome stability in the cells. Many endogenous defense enzymes are containing trace elements such as superoxide dismutase and metalloproteins. These enzymes are contributing in the detoxification of reactive oxidative species (ROS) induced by ionizing radiation in the cells. Zinc, copper, manganese, and selenium are main trace elements that have protective roles...

Original Articles
Clinical Investigation
Multi-institutional analysis of T3 subtypes and adjuvant radiotherapy effects in resected T3N0 non-small cell lung cancer patients
Yunseon Choi, Ik Jae Lee, Chang Young Lee, Jae Ho Cho, Won Hoon Choi, Hong In Yoon, Yun-Han Lee, Chang Geol Lee, Ki Chang Keum, Kyung Young Chung, Seok Jin Haam, Hyo Chae Paik, Kang Kyoo Lee, Sun Rock Moon, Jong-Young Lee, Kyung-Ran Park, Young Suk Kim
Radiat Oncol J. 2015;33(2):75-82.   Published online June 30, 2015
Purpose

We evaluated the prognostic significance of T3 subtypes and the role of adjuvant radiotherapy in patients with resected the American Joint Committee on Cancer stage IIB T3N0M0 non-small cell lung cancer (NSCLC).

Materials and Methods

T3N0 NSCLC patients who underwent resection from January 1990 to October 2009 (n = 102) were enrolled and categorized into 6 subgroups according to the extent of...

Can we omit prophylactic inguinal nodal irradiation in anal cancer patients?
Hakyoung Kim, Hee Chul Park, Jeong Il Yu, Doo Ho Choi, Yong Chan Ahn, Seung Tae Kim, Joon Oh Park, Young Suk Park, Hee Cheol Kim
Radiat Oncol J. 2015;33(2):83-88.   Published online June 30, 2015
Purpose

To evaluate the appropriateness of prophylactic inguinal nodal irradiation (PINI), we analyzed patterns of failure in anal cancer patients who were inguinal node-negative at presentation and did not receive PINI.

Materials and Methods

We retrospectively reviewed the records of 33 anal cancer patients treated by definitive concurrent chemoradiation therapy (CCRT) between 1994 and 2013. Radiotherapy consisted of a total dose of 44-45...

Clinical outcome of fiducial-less CyberKnife radiosurgery for stage I non-small cell lung cancer
In-Hye Jung, Si Yeol Song, Jinhong Jung, Byungchul Cho, Jungwon Kwak, Hyoung Uk Je, Wonsik Choi, Nuri Hyun Jung, Su Ssan Kim, Eun Kyung Choi
Radiat Oncol J. 2015;33(2):89-97.   Published online June 30, 2015
Purpose

To evaluate the treatment results in early stage non-small cell lung cancer patients who have undergone fiducial-less CyberKnife radiosurgery (CKRS).

Materials and Methods

From June 2011 to November 2013, 58 patients underwent CKRS at Asan Medical Center for stage I lung cancer. After excluding 14 patients, we retrospectively reviewed the records of the remaining 44 patients. All analyses were performed using SPSS...

Locoregionally advanced nasopharyngeal carcinoma treated with intensity-modulated radiotherapy plus concurrent weekly cisplatin with or without neoadjuvant chemotherapy
Chan Woo Wee, Bhumsuk Keam, Dae Seog Heo, Myung-Whun Sung, Tae-Bin Won, Hong-Gyun Wu
Radiat Oncol J. 2015;33(2):98-108.   Published online June 30, 2015
Purpose

The outcomes of locoregionally advanced nasopharyngeal carcinoma patients treated with concurrent chemoradiation (CCRT) using intensity-modulated radiotherapy (IMRT) with/without neoadjuvant chemotherapy (NCT) were evaluated.

Materials and Methods

Eighty-three patients who underwent NCT followed by CCRT (49%) or CCRT with/without adjuvant chemotherapy (51%) were reviewed. To the gross tumor, 67.5 Gy was prescribed. Weekly cisplatin was used as concurrent chemotherapy.

Results

With a median follow-up of...

Prognostic analysis of uterine cervical cancer treated with postoperative radiotherapy: importance of positive or close parametrial resection margin
Yi-Jun Kim, Kyung-Ja Lee, Kyung Ran Park, Jiyoung Kim, Wonguen Jung, Rena Lee, Seung Cheol Kim, Hye Sung Moon, Woong Ju, Yun Hwan Kim, Jihae Lee
Radiat Oncol J. 2015;33(2):109-116.   Published online June 30, 2015
Purpose

To analyze prognostic factors for locoregional recurrence (LRR), distant metastasis (DM), and overall survival (OS) in cervical cancer patients who underwent radical hysterectomy followed by postoperative radiotherapy (PORT) in a single institute.

Materials and Methods

Clinicopathologic data of 135 patients with clinical stage IA2 to IIA2 cervical cancer treated with PORT from 2001 to 2012 were reviewed, retrospectively. Postoperative parametrial resection margin...

Early treatment volume reduction rate as a prognostic factor in patients treated with chemoradiotherapy for limited stage small cell lung cancer
Joohwan Lee, Jeongshim Lee, Jinhyun Choi, Jun Won Kim, Jaeho Cho, Chang Geol Lee
Radiat Oncol J. 2015;33(2):117-125.   Published online June 30, 2015
Purpose

To investigate the relationship between early treatment response to definitive chemoradiotherapy (CRT) and survival outcome in patients with limited stage small cell lung cancer (LS-SCLC).

Materials and Methods

We retrospectively reviewed 47 patients with LS-SCLC who received definitive CRT between January 2009 and December 2012. Patients were treated with systemic chemotherapy regimen of etoposide/carboplatin (n = 15) or etoposide/cisplatin (n = 32)...

Clinical outcomes of adjuvant radiation therapy and prognostic factors in early stage uterine cervical cancer
Hyun Ju Kim, Woo Joong Rhee, Seo Hee Choi, Eun Ji Nam, Sang Wun Kim, Sunghoon Kim, Young Tae Kim, Gwi Eon Kim, Yong Bae Kim
Radiat Oncol J. 2015;33(2):126-133.   Published online June 30, 2015
Purpose

To evaluate the outcomes of adjuvant radiotherapy (RT) and to analyze prognostic factors of survival in the International Federation of Gynecology and Obstetrics (FIGO) IB-IIA uterine cervical cancer.

Materials and Methods

We retrospectively reviewed the medical records of 148 patients with FIGO IB-IIA uterine cervical cancer who underwent surgery followed by adjuvant RT at the Yonsei Cancer Center between June 1997 and...

Physics Contribution
Morphologic change of rectosigmoid colon using belly board and distended bladder protocol
Yeona Cho, Jee Suk Chang, Mi Sun Kim, Jaehwan Lee, Hwakyung Byun, Nalee Kim, Sang Joon Park, Ki Chnag Keum, Woong Sub Koom
Radiat Oncol J. 2015;33(2):134-141.   Published online June 30, 2015
Purpose

This study investigates morphologic change of the rectosigmoid colon using a belly board in prone position and distended bladder in patients with rectal cancer. We evaluate the possibility of excluding the proximal margin of anastomosis from the radiation field by straightening the rectosigmoid colon.

Materials and Methods

Nineteen patients who received preoperative radiotherapy between 2006 and 2009 underwent simulation in a prone...

Development of new on-line statistical program for the Korean Society for Radiation Oncology
Si Yeol Song, Seung Do Ahn, Weon Kuu Chung, Kyung Hwan Shin, Eun Kyung Choi, Kwan Ho Cho
Radiat Oncol J. 2015;33(2):142-148.   Published online June 30, 2015
Purpose

To develop new on-line statistical program for the Korean Society for Radiation Oncology (KOSRO) to collect and extract medical data in radiation oncology more efficiently.

Materials and Methods

The statistical program is a web-based program. The directory was placed in a sub-folder of the homepage of KOSRO and its web address is http://www.kosro.or.kr/asda. The operating systems server is Linux and...

Biology Contribution
Exome sequencing in a breast cancer family without BRCA mutation
Jae Myoung Noh, Jihun Kim, Dae Yeon Cho, Doo Ho Choi, Won Park, Seung Jae Huh
Radiat Oncol J. 2015;33(2):149-154.   Published online June 30, 2015
Purpose

We performed exome sequencing in a breast cancer family without BRCA mutations.

Materials and Methods

A family that three sisters have a history of breast cancer was selected for analysis. There were no family members with breast cancer in the previous generation. Genetic testing for BRCA mutation was negative, even by the multiplex ligation-dependent probe amplification method. Two sisters with breast cancer...

Case Report
The using of megavoltage computed tomography in image-guided brachytherapy for cervical cancer: a case report
Ekkasit Tharavichitkul, Suwapim Janla-or, Somsak Wanwilairat, Somvilai Chakrabandhu, Pitchayaponne Klunklin, Wimrak Onchan, Bongkot Supawongwattana, Razvan M. Galalae, Imjai Chitapanarux
Radiat Oncol J. 2015;33(2):155-159.   Published online June 30, 2015

We present a case of cervical cancer treated by concurrent chemoradiation. In radiation therapy part, the combination of the whole pelvic helical tomotherapy plus image-guided brachytherapy with megavoltage computed tomography of helical tomotherapy was performed. We propose this therapeutic approach could be considered in a curative setting in some problematic situation as our institution.

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