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- Review Articles
- Tumor hypoxia and reoxygenation: the yin and yang for radiotherapy
- Beom-Ju Hong
, Jeongwoo Kim , Hoibin Jeong , Seoyeon Bok , Young-Eun Kim , G-One Ahn
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Radiat Oncol J. 2016;34(4):239-249. Published online December 28, 2016
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Tumor hypoxia, a common feature occurring in nearly all human solid tumors is a major contributing factor for failures of anticancer therapies. Because ionizing radiation depends heavily on the presence of molecular oxygen to produce cytotoxic effect, the negative impact of tumor hypoxia had long been recognized. In this review, we will highlight some of the past attempts to overcome... |
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- Radiotherapy and immune checkpoint blockades: a snapshot in 2016
- Taeryool Koo
, In Ah Kim
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Radiat Oncol J. 2016;34(4):250-259. Published online December 28, 2016
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Immune checkpoint blockades including monoclonal antibodies (mAbs) of cytotoxic T-lymphocyte antigen-4 (CTLA-4), programmed death-1 (PD-1), and programmed death-ligand 1 (PD-L1) have been emerged as a promising anticancer therapy. Several immune checkpoint blockades have been approved by US Food and Drug Administration (FDA), and have shown notable success in clinical trials for patients with advanced melanoma and non-small cell lung cancer.... |
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- Original Articles
- Clinical Investigation
- Hypofractionated stereotactic body radiotherapy in low- and intermediate-risk prostate carcinoma
- Hun Jung Kim
, Jeong Hoon Phak , Woo Chul Kim
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Radiat Oncol J. 2016;34(4):260-264. Published online June 17, 2016
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Purpose: Stereotactic body radiotherapy (SBRT) takes advantage of low α/β ratio of prostate cancer to deliver a large dose in few fractions. We examined clinical outcomes of SBRT using CyberKnife for the treatment of low- and intermediate-risk prostate cancer.
Materials and Methods: This study was based on a retrospective analysis of the 33 patients treated with SBRT using CyberKnife for localized... |
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- Treatment outcomes after adjuvant radiotherapy following surgery for patients with stage I endometrial cancer
- Jiyoung Kim
, Kyung-Ja Lee , Kyung-Ran Park , Boram Ha , Yi-Jun Kim , Wonguen Jung , Rena Lee , Seung Cheol Kim , Hye Sung Moon , Woong Ju , Yun Hwan Kim , Jihae Lee
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Radiat Oncol J. 2016;34(4):265-272. Published online October 5, 2016
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Purpose: The purpose of this study is to evaluate the treatment outcomes of adjuvant radiotherapy using vaginal brachytherapy (VB) with a lower dose per fraction and/or external beam radiotherapy (EBRT) following surgery for patients with stage I endometrial carcinoma.
Materials and Methods: The subjects were 43 patients with the International Federation of Gynecology and Obstetrics (FIGO) stage I endometrial cancer who... |
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- Analysis of treatment outcomes for primary tonsillar lymphoma
- Yun Hee Lee
, Seok Goo Cho , Seung Eun Jung , Sung Hoon Kim , Joo Hyun O , Gyeong Sin Park , Suk Woo Yang , In Seok Lee , Chin Kook Rhee , Byung Ock Choi
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Radiat Oncol J. 2016;34(4):273-279. Published online October 31, 2016
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Purpose: Although each Waldeyer’s ring sub-site is considered an independent prognostic factor, few studies have assessed the prognosis and treatment of tonsillar lymphoma. Treatment outcomes were analyzed in patients with primary tonsillar lymphoma who were treated with chemotherapy and radiotherapy (RT).
Materials and Methods: Nineteen patients with diffuse large B-cell lymphoma were evaluated, with a median follow-up of 53 months. Age,... |
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- Early hypopharyngeal cancer treated with different therapeutic approaches: a single-institution cohort analysis
- Nalee Kim
, Jeongshim Lee , Kyung Hwan Kim , Jong Won Park , Chang Geol Lee , Ki Chang Keum
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Radiat Oncol J. 2016;34(4):280-289. Published online October 31, 2016
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Purpose: Early hypopharyngeal squamous cell carcinoma (HPSCC) is a rarely diagnosed disease, for which the optimal treatment has not been defined yet. We assessed patterns of failure and outcomes in early HPSCC treated with various therapeutic approaches to identify its optimal treatment.
Materials and Methods: Thirty-six patients with stage I (n = 10) and II (n = 26) treated between January... |
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- The impact of radiotherapy on clinical outcomes in parameningeal rhabdomyosarcoma
- Yunseon Choi
, Do Hoon Lim
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Radiat Oncol J. 2016;34(4):290-296. Published online September 13, 2016
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Purpose: Radiotherapy (RT) is considered a mainstay of treatment in parameningeal rhabdomyosarcoma (PM-RMS). We aim to determine the treatment outcomes and prognostic factors for PM-RMS patients who treated with RT. In addition, we tried to evaluate the adequate dose and timing of RT.
Materials and Methods: Twenty-two patients with PM-RMS from 1995 to 2013 were evaluated. Seven patients had intracranial... |
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