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J Korean Soc Ther Radiol > Volume 11(2); 1993 > Article
Journal of the Korean Society for Therapeutic Radiology 1993;11(2): 277-284.
Induction Chemotherapy Plus Radiation Compared with Surgery Plus Radiation in Patients with Advanced Laryngeal and Hypopharyngeal Cancer
Ki Chang Keum, Chang Geol Lee, Gwi Eon Kim, Kyung Hee Lee
Department of Radiation Oncology, Yonsei University College of Medicine, Yonsei Cancer Conter, Seoul, Korea.
ABSTRACT
BACKGROUND: We performed a retrospective study in patients with previously untreated advanced(Stage III or IV) laryngeal and hypopharyngeal cancer to compare the results of induction chemotherapy followed by definitive radiation therapy (CT+RT) with those of conventional laryngectomy and postoperative radiation therapy (OP+RT). METHOD: Between 1985 and 1990, twenty four patients were treated with two or three courses of chemotherapy and radiation therapy(66~75 Gy). Twenty-five patients were received laryngectomy and radical neck dissection(except 3 patients) and postoperative radiation therapy (55~04 Gy).
RESULT:
After a median follow-up of 20 months, the actuarial 5-year overall survival rate was 24% (chemotherapy group) and 36% (op group).(P>0.1). The local control rate was the 65%,(13/20) and 68.2%(15/22).(P>0.1). The rate of laryngeal preservation was 65%(13/20) in chemotherapy group.
CONCLUSION:
Induction chemotherapy and definitive radiation therapy can be effective in preserving the larynx in a high percentage of patients with advanced laryngeal and hypopharyngeal cancer.
Key Words: Induction chemotherapy, Radiotherapy, Laryngeal and hypopharyngeal cancer
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