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Journal of the Korean Society for Therapeutic Radiology 1993;11(2): 277-284. |
| Induction Chemotherapy Plus Radiation Compared with Surgery Plus Radiation in Patients with Advanced Laryngeal and Hypopharyngeal Cancer |
| Ki Chang Keum, Chang Geol Lee, Gwi Eon Kim, Kyung Hee Lee |
| Department of Radiation Oncology, Yonsei University College of Medicine, Yonsei Cancer Conter, Seoul, Korea. |
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| ABSTRACT |
BACKGROUND: We performed a retrospective study in patients with previously untreated advanced(Stage III or IV) laryngeal and hypopharyngeal cancer to compare the results of induction chemotherapy followed by definitive radiation therapy (CT+RT) with those of conventional laryngectomy and postoperative radiation therapy (OP+RT).
METHOD: Between 1985 and 1990, twenty four patients were treated with two or three courses of chemotherapy and radiation therapy(66~75 Gy). Twenty-five patients were received laryngectomy and radical neck dissection(except 3 patients) and postoperative radiation therapy (55~04 Gy).
RESULT:
After a median follow-up of 20 months, the actuarial 5-year overall survival rate was 24% (chemotherapy group) and 36% (op group).(P>0.1). The local control rate was the 65%,(13/20) and 68.2%(15/22).(P>0.1). The rate of laryngeal preservation was 65%(13/20) in chemotherapy group.
CONCLUSION:
Induction chemotherapy and definitive radiation therapy can be effective in preserving the larynx in a high percentage of patients with advanced laryngeal and hypopharyngeal cancer. |
| Key Words:
Induction chemotherapy, Radiotherapy, Laryngeal and hypopharyngeal cancer |
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