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J Korean Soc Ther Radiol > Volume 11(1); 1993 > Article
Journal of the Korean Society for Therapeutic Radiology 1993;11(1): 97-102.
The Results of Radiation Therapy of Limited Stage Small Cell Lung Cancer
Sung Hwan Kim, Byung Ok Choi, Hak Joon Gil, Sei Chul Yoon, Yong Whee Bahk, Kyung Sub Shinn, Hoon Kyo Kim, Kyung Sik Lee
1Department of Therapeutic Radiology, Kangnam ST. Mary's Hospital, Catholic University Medical College, Seoul, Korea.
2Department of Internal Medicine, Kangnam ST. Mary's Hospital, Catholic University Medical College, Seoul, Korea.
A retrospective analysis of various characteristics in 32 limited stage small cell lung cancer patients treated at the Department of Therapeutic Radiology in Kangnam ST. Mary's Hospital, Catholic University Medical College from April 1983 to September 1991, was carried out to identify factors which had prognostic signficance for survival from intiation of radiation therapy. There were 26 men and 6 women. Median age was 63 years )range:24-78 years). The follow up duration was 1.5 to 44 months(median:9 months). External radiation therapy was done with daily 160-180 cGy, 5 fraction/week, total of 1000-6660 cGy (median: 4500 cGy) to the mediatinum by 6 MY linear accelerator. Of 32 patients, 27 (84.4%) patients were treated with combined modality (chemotheraphy plus radiation therapy), and 5 (15.6%) patients were treated with radiation theraphy only. Complete responders were 12 patients (37.5%), partial responders were 11(34.4%), and no responders were 9(28.1%). Karnofsky performance status over 70(p< 0.007), chemotherapy regimen (CAV, PV, and CAV+PV) (p<0.04), 6 or more cycles of chemotherapy (p<0.007), radiation therapy over 4500 cGy (p<0.03), and radiation therapy responder (CR+PR) (p<0.003) showed a significantly favorable influence on 1 year survival rate. Age (p=0.545), sex (p=0.666), presence of superior vena cava syndrome (p=0.719), prophylactic cranial irradiation (p=0.217), and radiation therapy duration (p=0.491) had no effect on survival. Radiation induced side effects were transient esophagitis in 11(34%), general weakness in 9(28%), gastrointestianl sysptoms in terms of nausea, vomiting and indigestion in 5(15%) and leukopenia in 1(3%).
Key Words: Radiation Therapy, Limited Stage Small Cell Lung Cancer
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