The interaction of radiation and 5-luorouracil (5-U) on mouse jejunal crypt cells was studied using the microcolony survival assay. 150mg/kg of 5-U was injected intraperitoneally 15 minutes before irradiation and 6 hours after irradiation. Jejunal crypt cells of mouse survived more when 5-U was given 15 minutes before irradiation than giving it 6 hours after irradiation. The mean lethal doses...

From July 1979 through March 1985, 112 patients with carcinoma of the uterine cervix were treated by whole pelvis irradiation and intracavitary radiation with Cs-37. The treatment consisted of 3600rad-200rad to the whole pelvis by parallel opposing portals, 5 days per week, 180-00rad per day. Parametrial boost with 400-00rad was given in 60 patients. 2 intracavitary Cs-37 radiation using TAO...

The early carcinoma of the uterine cervix may be treated by either radical surgery or radical radiotherapy according to the patient's characteristics, and the survival is high with either treatment. But, because of the size of the lesion, metastasis to lymph nodes, and vascular space invasion by tumor have all been shown to influence recurrence and survival, postoperative radiotherapy may...

This is a retrospecitve analysis of 54 patients with stage I or II Non-odgkin's lymphoma involving the head and neck region treated with curative radiotherapy in the Department of Therapeutic Radiology, Seoul National University Hospital during the period of February 1979 through September 1982. The minimum follow-p period was 24 months. The review of histologic slides was available in 36 cases....

A retrospective analysis was undertaken of 46 patients who were referred with squamous cell carcinoma of the esophagus during the period of March 1979 through October 1982, and who were treated by curative radiotherapy in the Department of Therapeutic Radiology Soul National University Hospital. The overall tow-ear actuarial survival rate was 20%. Survival was analyzed with respect to the site of the...

A retrospective analysis of 29 patients with glottic cancer, treated at the Department of Therapeutic Radiology, Seoul National University Hospital. 97% of the patients was male. Of the 29 patients, stage T1N0M0 comprised 31%, T2N0M0 52%, and stage T3N0M0 14%. Local control rate with radical readiotherapy was 78% for stage T1N0M0, 60% for stage T2N0M0, and 50% for stage T3N0M0. 57%...

Radiation therapy was the treatment of choice for CML in the past, in the form of Sl or radioactive phosphorus. Its use has been replaced to a large extent by various chemotherapeutic agents. Recently Sl in CML has been used, both to relieve painful splenomegaly and to take advantage of an indirect effect of Sl on unirradiated bone marrow. We...

The peripheral dose distributions of wedge fields of Co-0 gamma-ay and 10MV x-ay were measured by the solid state detector controlled by means of semiautomatic water phentom system. The measurements were made on the principal plane parallel to the cross section of wedge filter (blade and ridge direction). For parallel motion of the detector to the beam axis the distance...

Radiation effect on mammals, especially on hematologic changes, has been studied since discovery of x-ay. Various experimental animals were tried for radiobiological studies. 72 hybrid mice with conventional ffaction (5X/week), large abdominal field (2 x3cm, from symphysis pubic to xyphoid process) were used. Body weight was declined gradually by increasing irradiation doses, nadir was about 29.7% in male ; 30.4% in...

A simple intracavitary irradiation of carcinoma of the nasopharynx has been found useful as a supplementary radiation boost to the primary site, and as a method of re-rradiation for recurrence in the nasopharynx. Hopefully, local tumor control can be enhanced by employing this technique.

Intraocular melanoma is the most common primary occular malignancy in adult above the age of 20. Before treatment of intraocular melanoma, it is essential to do complete work-ps including LFT (LDH, SGPT), chest X-ay, whole body bone scan. Also, liver-pleen and brain scan will be done if clinically indicated. Though, malignant melanoma is radioresistant, however, show rapid tumor shrinkage after irradiation...

The mouse is one of the most popular experimental animal which has wide variation of strains, diet, environment, breeding technique, and diurnal cycle. Total 731 mice (male 372, female 359) were used for the standard data of our laboratory. Proper age for experiment were 30 +/- days, body weight were 25 +/- gm(male), 23 +/- gm. (female), minimal diurnal variation...

Even though the mechanism and the nature of radiation induced pneumonitis, esophagitis and gastroenteritis were detailed by many authors, complicated secondary infection is still serious problem, sometimes fatal, even today. We experience a case of multiple pyogenic abscess in subcutaneous tissue of the back and both kidneys which could not differenciate from multiple metastatic sarcoma grossly, and report with review...