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ORIGINAL ARTICLE 2025 January 15
Feasibility and safety study of ultra-hypofractionated neoadjuvant radiotherapy to margins-at-risk in retroperitoneal sarcoma
Purpose: Retroperitoneal sarcomas (RPS) are rare tumors that present unique challenges, often due to late presentation, and the proximity of critical organs makes complete surgical resection challenging. This study aimed to assess the feasibility of neoadjuvant short-course radi...
ORIGINAL ARTICLE 2024 December 19
Reducing clinical target volume margins for multifocal glioblastoma: a multi-institutional analysis of patterns of recurrence and treatment response
Purpose: No guidelines exist to delineate radiation therapy (RT) targets for the treatment of multiple glioblastoma (mGBM). This study analyzes margins around the gross tumor volume (GTV) to create a clinical target volume (CTV), comparing response parameters and modalities of r...
ORIGINAL ARTICLE 2025 March 27
Promising application of nano-WO3/epoxy composite in intensity-modulated brachytherapy: a simulation study
Purpose: Implementing intensity-modulated brachytherapy (IMBT) techniques with high-energy sources like 60Co has always been challenging due to the clinical limitations of the applicator dimensions. This study aims to investigate using tungsten trioxide nanoparticles/epoxy compo...
ORIGINAL ARTICLE 2025 February 26
Hounsfield units predict vertebral compression fractures in gastric cancer survivors after adjuvant irradiation
Purpose: This study aimed to investigate the risk factors and predictive value of vertebral Hounsfield units (HUs) for vertebral compression fracture (VCF) development in gastric cancer (GC) patients who received adjuvant radiotherapy (RT). Materials and Methods: We retrospecti...
ORIGINAL ARTICLE 2025 March 17
Planning evaluation of stereotactic magnetic resonance–guided online adaptive radiosurgery for kidney tumors close to the organ at risk: is it valuable to wait for good timing to perform stereotactic radiosurgery?
Purpose: This study aimed to investigate changes in target coverage using magnetic resonance–guided online adaptive radiotherapy (MRgoART) for kidney tumors and to evaluate the suitable timing of treatment. Materials and Methods: Among patients treated with 3-fraction MRgoART ...
CASE REPORT 2025 March 10
Long-term outcomes of radiotherapy for inoperable benign soft tissue tumors in the skull base or head
This study aimed to evaluate the long-term efficacy and complication of radiotherapy for benign soft tissue tumors. Five cases of benign soft tissue tumors (two plexiform neurofibromas, two juvenile nasopharyngeal angiofibromas, and one cavernous sinus hemangioma) who underwent ...

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Current Issue
Volume 43(1); March 2025
Original Article
Technique and outcomes of high-dose-rate interstitial brachytherapy for lip and buccal mucosa cancer: emphasis on cosmetic results
Subhas Pandit, Simit Sapkota, Jeebana Bhandari, Abish Adhikari, Deepak Yadav, Rijendra Yogal, Rajan Prajapati, Sangam Rayamajhi, Sunil Shrestha, Anjani Kumar Jha
Received October 25, 2024  Accepted March 6, 2025  

Purpose: High-dose-rate (HDR) brachytherapy is a promising treatment modality for organ and function preservation in lip and oral cavity cancers. This study aims to describe the technique and assess clinical outcomes of HDR interstitial brachytherapy in patients diagnosed with lip and buccal mucosa cancer treated in a comprehensive cancer center. Materials and Methods: We conducted a retrospective analysis of six lip...
DOI: https://doi.org/10.3857/roj.2024.00682    [Epub ahead of print]
Implications of interfractional bladder volume variations in proton beam therapy for rectal cancer
Johanna Färlin, Bruno Sorcini, Karin Söderkvist, Alexander Valdman
Received October 4, 2024  Accepted March 13, 2025  
Purpose This study evaluated interfractional bladder volume variations and the resulting dosimetric changes during short-course radiotherapy (SCRT) 5X5Gy (RBE) in patients with locally advanced rectal cancer. Materials and methods Twenty patients received either protons or photons with daily cone-beam CT (CBCT). All patients received the same drinking instructions prior to the planning CT and each fraction. For each patient, VMAT and PBT plans...
DOI: https://doi.org/10.3857/roj.2024.00654    [Epub ahead of print]
Case Report
Magnetic resonance linear accelerator boost for para-urethral cancer: a new treatment paradigm replacement for brachytherapy
Amir Owrangi, David Chiu, Star Okolie, Kevin Albuquerque
Received August 31, 2024  Accepted January 8, 2025  
This study evaluates the use of magnetic resonance–guided radiation therapy (MRgRT) as an alternative to brachytherapy in treating para-urethral gynecological cancers, particularly for patients who are not candidates for brachytherapy. Five female patients with advanced para-urethral gynecological cancers underwent MRgRT using a custom 3-dimensional-printed intravaginal cylinder for image registration and treatment alignment. MRgRT was administered as a five-fraction adaptive boost...
DOI: https://doi.org/10.3857/roj.2024.00584    [Epub ahead of print]
An isoradiotopic response of lichen planus: a case report and review of literature
Arun Somasundaram, Gajula Sai Avanija, Malathi Munisamy, Bheemanathi Hanuman Srinivas, Gunaseelan Karunanithi
Received October 22, 2024  Accepted December 27, 2024  
Radiation-induced cutaneous side effects are well known; however, the isoradiotopic phenomenon presenting as lichen planus is underreported in the literature. It is imperative to be aware of this entity to manage the patients accordingly. Herein, we report a 31-year-old male, a known case of carcinoma glottis who developed lichen planus confined to the radiation site and presented with a review...
DOI: https://doi.org/10.3857/roj.2024.00668    [Epub ahead of print]
Original Article
Role of radiotherapy in the management of breast cancer with skin involvement
Sun Ho Min, Jee Suk Chang, Yong Bae Kim, Seo Hee Choi, Ik Jae Lee, Jaiwo Lee, Hyeok Choi, Youn Ji Hur, Hwa Kyung Byun
Received February 13, 2024  Accepted October 21, 2024  

Purpose: This study aimed to evaluate the effect of radiotherapy (RT) on symptomatic relief and tumor control in patients with breast cancer with skin involvement. Materials and Methods: This retrospective study included patients who received palliative RT of the breast or chest wall for breast cancer with skin involvement. Progression-free survival, freedom from local progression (FFLP), and symptomatic response were evaluated....
DOI: https://doi.org/10.3857/roj.2024.00122    [Epub ahead of print]
Dosimetric analysis of different whole brain radiotherapy treatment planning methods: three types of 3-dimensional versus hippocampal avoidant
Jonathan Robert Gabriel, Angela Mariah Locke, Brian William Miller, Jared Rex Robbins
Received February 2, 2024  Accepted September 13, 2024  

Purpose: Our purpose was to compare four whole brain radiotherapy (WBRT) delivery types: opposed lateral (OL) 3-dimensional-conformal radiotherapy (3D-CRT), a novel opposed lateral sparing (OLS) 3D-CRT technique, 3D optimized dynamic conformal arcs (optDCA), and hippocampal-avoidant WBRT (HA-WBRT). Materials and Methods: Ten patients previously undergoing HA-WBRT were retrospectively planned using OL, OLS, and optDCA techniques. OLS technique involved multi-leaf collimator (MLC) modifications...
DOI: https://doi.org/10.3857/roj.2023.01039    [Epub ahead of print]
Optimal radiotherapy dose and fractionation for stereotactic radiotherapy in excised brain metastases
Kelvin Cheuk Man Cheung, Gavin Tin Chun Cheung, Ka Man Cheung, James Chung Hang Chow, Kwok Hung Au
Received August 23, 2024  Accepted November 8, 2024  

Purpose: Stereotactic radiotherapy (SRT) is an important adjunctive treatment after excision of brain metastases. We investigated efficacy and safety outcomes of such treatment and the impact of radiotherapy dose fractionations in a real-world multi-center cohort. Materials and Methods: All patients who received resection cavity SRT between 2018–2022 were identified from institutional databases of two tertiary oncology centers. Patient and treatment characteristics...
DOI: https://doi.org/10.3857/roj.2024.00556    [Epub ahead of print]
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