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Table of Contents | June, 2023  Vol. 41  No.2 Previous Issue | Next Issue | Archive
In this issue:



Review Article
Research progress and treatment of radiation enteritis and gut microbiota
Huiwen Ren, Qi Wu, Zhiqiang Sun, Mingming Fang, Jun Liu, Judong Luo
Radiat Oncol J. 2023;41(2):61-68.   Published online June 28, 2023
Radiation enteritis is a kind of intestinal radiation injury in patients with pelvic and retroperitoneal malignancies after radiotherapy, and its occurrence and development process are very complicated. At present, studies have confirmed that intestinal microecological imbalance is an important factor in the formation of this disease. Abdominal radiation causes changes in the composition of the flora and a decrease in...
Original Articles
Proton therapy for reducing heart and cardiac substructure doses in Indian breast cancer patients
Sapna Nangia, Nagarjuna Burela, M. P. Noufal, Kartikeswar Patro, Manoj Gulabrao Wakde, Dayanada S. Sharma
Radiat Oncol J. 2023;41(2):69-80.   Published online June 1, 2023

Purpose: Indians have a higher incidence of cardiovascular diseases, often at a younger age, than other ethnic groups. This higher baseline risk requires consideration when assessing additional cardiac morbidity of breast cancer treatment. Superior cardiac sparing is a critical dosimetric advantage of proton therapy in breast cancer radiotherapy. We report here the heart and cardiac-substructure doses and early toxicities in...
Evaluation of the role of inflammatory blood markers in predicting the pathological response after neoadjuvant chemoradiation in patients with locally advanced rectal cancer
Shahram Manoochehry, Hamid Reza Rasouli, Fathollah Ahmadpour, Alireza Keramati
Radiat Oncol J. 2023;41(2):81-88.   Published online June 28, 2023

Purpose: This study aimed to evaluate the role of inflammatory blood markers in predicting the pathological response rate after neoadjuvant chemoradiation (neo-CRT) in patients with locally advanced rectal cancer (LARC). Materials and Methods: In this prospective cohort study, we analyzed the data of patients with LARC who underwent neo-CRT and surgical removal of the rectal mass between 2020 and 2022 in...
The effects of low-dose radiation therapy in patients with mild-to-moderate Alzheimer's dementia: an interim analysis of a pilot study
Aryun Kim, Jeonghwan Lee, Hansol Moon, Chulhan Kim, Min Young Yoo, Woo Yoon Park, Won Dong Kim, Young-Seok Seo
Radiat Oncol J. 2023;41(2):89-97.   Published online June 26, 2023

Purpose: We aimed to determine whether low-dose radiotherapy (LDRT) is effective in patients with Alzheimer disease (AD). Materials and Methods: We included patients according to the following criteria: probable Alzheimer's dementia according to the New Diagnostic Criteria for Alzheimer’s Disease; confirmation of amyloid plaque deposits on baseline amyloid positron emission tomography (PET); a Korean Mini-Mental State Examination 2nd edition (K-MMSE-2) score...
Radiotherapy trend in elderly hepatocellular carcinoma: retrospective analysis of patients diagnosed between 2005 and 2017
Bong Kyung Bae, Jeong Il Yu, Hee Chul Park, Myung Ji Goh, Yong-Han Paik
Radiat Oncol J. 2023;41(2):98-107.   Published online June 22, 2023

Purpose: To report the trends of radiotherapy in the management of elderly patients with hepatocellular carcinoma (HCC). Materials and Methods: We retrospectively reviewed patients who entered HCC registry of Samsung Medical Center between 2005 and 2017. Patients who were 75 years or older at the time of registration were defined as elderly. They were categorized into three groups based on the...
Nationwide changes in radiation oncology travel and location of care before and during the COVID-19 pandemic
Alexandra N. De Leo, Fantine Giap, Matthew M. Culbert, Nicolette Drescher, Ryan J. Brisson, Vincent Cassidy, Etzer Michelet Augustin, Anthony Casper, David H. Horowitz, Simon K. Cheng, James B. Yu
Radiat Oncol J. 2023;41(2):108-119.   Published online June 22, 2023

Purpose: Patients with cancer are particularly vulnerable to coronavirus disease (COVID). Transportation barriers made travel to obtain medical care more difficult during the pandemic. Whether these factors led to changes in the distance traveled for radiotherapy and the coordinated location of radiation treatment is unknown. Materials and Methods: We analyzed patients across 60 cancer sites in the National Cancer Database...
Impact of radiation on immune cells in patients with low-grade brain tumor: Identifying critical factors affecting lymphopenia and neutrophil-to-lymphocyte ratio
Yoo Kyung Choi, Hong Seok Jang, Byung Ok Choi, Sea-Won Lee, Jin Ho Song
Radiat Oncol J. 2023;41(2):120-128.   Published online June 28, 2023

Purpose: Studies about the effect of radiation therapy (RT) on immune cells are usually limited to a high-grade glioma mostly exposed to chemotherapy and a high dose of steroid which also could affect immune cells. The purpose of this retrospective analysis of low-grade brain tumor patients treated by RT alone is to determine significant factors influencing neutrophil-to-lymphocyte ratio (NLR), absolute...
Radiotherapy combined with immunotherapy could improve the immune infiltration of melanoma in mice and enhance the abscopal effect
Yufeng Zheng, Xue Liu, Na Li, Aimei Zhao, Zhiqiang Sun, Meihua Wang, Judong Luo
Radiat Oncol J. 2023;41(2):129-139.   Published online June 29, 2023

Purpose: To analyze the gene mutation, immune infiltration and tumor growth of primary tumor and distant tumor under different treatment modes. Materials and Methods: Twenty B16 murine melanoma cells were injected subcutaneously into the of both sides of the thigh, simulating a primary tumor and a secondary tumor impacted by the abscopal effect, respectively. They were divided into blank control...
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